9:36 PM
maestr0
Experiments with mice show that resveratrol prolongs life and reversing some of the damage caused by obesity. This study is too short to explore the effects on life expectancy, but generally confirms many of the established metabolic effects in mice.
The most common effects were similar to those observed in severe caloric deficit, which was also found to improve metabolism and longevity in different mammalian species.
In this study, 11 otherwise healthy obese men were randomized to placebo or 150 mg of resveratrol daily for 30 days. after 4-week cleansing period, the groups were crossed (the placebo group switched to the active ingredient and vice versa).
The following differences were found after 30 days intake of resveratrol:
- Systolic pressure was 124.7 mm Hg in the resveratrol group vs 130.5 in the placebo group.
- Was no observed effect on body weight.
- After consuming a liquid test meal participants reached peak glucose and insulin responses within 30 minutes in the placebo group versus 60 minutes in resveratrol group.
- Levels of leptin and leukocytes were significantly lower in those receiving resveratrol
- Resveratrol in patients observed lower levels of markers of systemic inflammation (interleukin-6 and tumor necrosis factor alpha)
- In the resveratrol group were reported significantly lower levels of glucose and insulin, which focuses on improved insulin sensitivity.
- Lower triglyceride levels in the resveratrol group
- Lower accumulation of lipids in the liver in resveratrol
- Analysis of biopsies from vastus lateralis musul found different expression of 469 genes. Several genes associated with mitochondrial phosphorylation oksilitelno were adjusted upward, while those associated with inflammation - adjusted downwards.
